教育经历

1997.08 – 2001.08 美国哈佛大学化学和化学生物学系🧒🏽，有机化学专业，博士后

1993.08 – 1997.08 美国弗吉尼亚理工大学化学系🟪，有机化学专业，博士

1983.09 – 1985.12 东北大学化学系，分析化学专业，硕士

1979.09 – 1983.07 河南师范大学化学系🌝，化学专业，学士

工作经历

2014.01 – 现在     杏悦娱乐👩🏼‍🎨，讲座教授（2022.10-现在）、特聘教授（2014.01 – 2022.9），

博士生导师🏊🏻‍♂️；上海市药物研发协同创新中心化学部主任

2008.10 – 2013.12  葛兰素史克制药公司(上海)研发中心📂，副总监

2001.08 – 2008.10  葛兰素史克制药公司(美国费城)研发中心👩🏼‍🔬，研究员

1985.12 – 1993.08  西安建筑科技大学环境工程杏悦，助教、讲师

研究方向

1. 自身免疫小分子药物发现

2. 肿瘤免疫小分子药物发现

3. 蛋白降解药物（PROTAC、MG）发现

代表性论著

1.      Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang*, and Qiong Xie*. Discovery of Biaryl Amide Derivatives as Potent, Selective, and Orally Bioavailable RORγt Agonists for Cancer Immunotherapy. J. Med. Chem., 2023, 66, 16091-16108.

2.      Chenyu Zhu, Shuyin Ze, Ronghui Zhou, Xinyu Yang, Haojie Wang, Xiaolei Chai, Meimiao Fang, Mingyao Liu, Yonghui Wang,* Weiqiang Lu,* Qiong Xie.* Discovery of Pyridinone Derivatives as Potent, Selective and Orally Bioavailable Adenosine A2A Receptor Antagonists for Cancer Immunotherapy. J. Med. Chem., 2023, 66, 4734-4754.

3.      Fazhi Yu, Chenyu Zhu, Shuyin Ze, Haojie Wang, Xinyu Yang, Mingyao Liu, Qiong Xie*, Weiqiang Lu*, and Yonghui Wang.* Design, Synthesis, and Bioevaluation of 2-Aminopteridin-7(8H)-one Derivatives as Novel Potent Adenosine A2A Receptor Antagonists for Cancer Immunotherapy. J. Med. Chem., 2022, 65, 4367–4386.

4.      Ji-An Chen, Hui Ma, Zehui Liu, Jinlong Tian, Sisi Lu, Wenqing Fang, Weiqiang Lu, Qiong Xie,* Jin Huang,* Yonghui Wang.*Discovery of Orally Available RORgt/DHODH Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. J. Med. Chem.,2022, 65, 592-615

5.      Nannan Sun, Qiong Xie, Yongjun Dang,* Yonghui Wang.* Agonist Lock Touched and Untouched Retinoic Acid ReceptorRelated Orphan Receptor-γt (RORγt) Inverse Agonists: Classification Based on the Molecular Mechanisms of Action. J. Med. Chem.,2021, 64, 10519-10536.

6.      Fazhi Yu, Chenyu Zhu, Qiong Xie, Yonghui Wang.*Adenosine A2a Receptor Antagonists for Cancer Immunotherapy. J. Med. Chem., 2020, 61, 12196-12212

7.      Ruomeng Qiu, Yonghui Wang.*Retinoic acid receptor-related orphan receptor-gamma-t (RORgt) agonists as potential small molecular therapeutics for cancer immunotherapy. J. Med. Chem., 2018, 61, 5794-5804