教育经历
1979.09 – 1983.08 华东师范大学化学系(本科)
1983.09 – 1986.06 华东师范大学化学系(研究生)
工作经历
1986.07 – 1988.09 上海医科大学杏悦注册娱乐🧘🏿♂️🤵🏻♂️,助教
1988.10 – 1994.09 上海医科大学杏悦注册娱乐,讲师
1994.10 – 2011.08 杏悦,副教授
2011.09 – 至今 杏悦🚎,教授
1997.09 - 1998.03 日本长崎大学药学部进修
主要科研贡献
3.建立了多种体内药物浓度的测定方法,药物涉及多种类别,包括小分子蛋白(多肽)药物的测定,比如建立了测定人血中和尿中重组双功能水蛭素方法,该方法具有准确、灵敏,选择性好,血浆用量少等优点,成功应用于该药物的临床试验和研究。
4.开展了多个药物的质量标准研究🫴🏿,在此过程中💂🏿🏓,通过定性定量分析为合成工艺的改进提供了非常重要的帮助,为药品的质量控制提供了合理有用的方法。
5.近年来开始进入疾病的代谢组学研究领域🍒,目前运用代谢组学方法对CTCL生物标志物进行研究👳🏼♂️、已经筛寻得到数十个潜在的生物标志物。 通过代谢组学的研究将为疾病的诊断提供依据,进一步可展望靶点药物研发💁🏼♂️。
6.发表论文50余篇🙆,申请专利6项(获得授权4项)🧜🏿♀️。
7.培养的博士生2人; 培养硕士生15人👲🏼☪️,获得上海市优秀硕士毕业论文1人,上海市优秀硕士毕业生1人✧。
承担科研项目情况
国家自然科学基金面上项目:木鳖子抗肿瘤药效的物质基础研究(NSFC C190703)🚵🏽;基于LC-MS技术的CTCL生物标志物的发现及其生物学意义研究(NSFC 81272988)
上海市自然科学基金项目🏩:霉酚酸酯药动学与器官移植存活率相关性研究(03ZR14010)
获奖及荣誉
2009.11 上海市科技进步三等奖
2009.12 上海市研究生优秀成果(学位论文),导师
2011.05 上海市优秀发明选拔赛优秀发明银奖
研究方向
1.新药质量标准的建立
2.体内药物分析方法研究
3.代谢组学研究
代表性论著
1.Xia Li, Yu Wang, Qingyuan Zhou, Yunqiu Yu*, Lihong Chen, Jie Zheng, A sensitive method for digoxin determination using formate-adduct ion based on the effect of ionization enhancement in liquid chromatograph-mass spectrometer, Journal of Chromatography B[J], 2015, 978–979: 138-44.
2.Qing-Yuan Zhou, Yue-Lin Wang, Xia Li, Xiao-Yan Shen, Ke-Jia Li, Jie Zheng, Yun-Qiu Yu*, Metabolics Investigation of Cutaneous T Cell Lymphpma Based on UHPLC-QTOF/MS. Asian Pacific journal of cancer prevention[J]. 2014;15(13):5417-21.
3.Xiaoyun Liu, Shuiqing Zheng, Zheng Jiang, Chen Liang, Rong Wang, Zhe Zhou, Yurong Zhang, Yunqiu Yu*, Rapid separation and identification of Strychnos alkaloids metabolites in rats by ultra high performance liquid chromatography with linear ion trap Orbitrap mass spectrometry Journal of Separation Science 2014(37)🤳🏿,764–774
4.Qixin Dong,Jiajun Zhu📴💿,Qiang Sui,Chao Tang,Xiaomei Wang,Yunqiu Yu*😻,Optimization of mobile phase for the determination of Esomeprazole and related compounds and investigation of stress degradation by LC–MS Journal of Separation Science 2013(36)✍️,1200–1208
5.Zhuhong Yu, Zhongping Wu, Feijun Gong, Rong Wong, Chen Liang, Yurong Zhang*, Yunqiu Yu* Simultaneous determination of six toxic alkaloids in human plasma and urine using capillary zone electrophoresis coupled to time-of-flight mass spectrometry Journal of Separation Science 2012, 35(20), 2773–2780 ISSN 1615-9314
6.Zhi-Yan Lin, Xiaoyun Liu, Fan Yang, Yun-Qiu Yu, Structural characterization and identification of five triterpenoid saponins isolated from Momordica cochinchinensis extracts by liquid chromatography/tandem mass spectrometry International Journal of Mass Spectrometry 328–329 (2012) , 43–66 ISSN 1387-3806
7.Le Pan, Yunqiu Yu*, Longwei Sun, An LC–MS Method for a Hexokinase Inhibitor Study Based on Adenosine 50-Triphosphate Determination and Application to the Anticancer Mechanism of Momordica cochinchinensis, Chromatographia, 2010 (72) 425-430 ISSN 0009-5893(print) 1612-1112(online)
8.Le Pan, Yanping Guo, Zhongdong Li, Jun Chen, Tian Jiang, Yunqiu Yu*, Longwei Sun,Simultaneous Determination of Levodopa, Benserazide and 3-O-Methyldopa in Human Serum by LC–MS–MS🚄,Chromatographia, 2010 (72) 627-633 ISSN 0009-5893(print) 1612-1112(online)
9.Shengmin Su, Yunqiu Yu*, Online preconcentration of recombinant Arg-Gly-Asp-hirudin using dynamic pH junction for analysis in human urine samples by capillary electrophoresis-mass spectrometry. Journal of Chromatography A, 2009, (1216) 1490–1495 ISSN 0021-9673
10.Shengmin Su, Yunqiu Yu, Wei Mob, Yanling Zhang, Houyan Song, Qinfen Chen, Yi Xie,A development of LC–MS method combining ultrafiltration and lyophilization for determination of r-RGD-Hirudin in human serum Journal of Chromatography B,2008👳🏻♂️🛷,870 27-31 ISSN 1570-0232